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Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's Energetic metabolites. The result of CYP3A4 inducers on cariprazine exposure has not been evaluated and the net effect is unclear.pentobarbital will reduce the extent or influence of diclofenac by impacting hepatic enzyme CYP2C9/ten metabolism. Minimal/Signi